tl;dr: A JACC study of 260,000+ people tracked over ~20 years found that waist circumference (WC) and waist-to-hip ratio (WHR) predict cardiovascular disease risk more accurately than BMI alone. Normal-BMI individuals with high WC or WHR had 15-50% greater risk across most cardiovascular outcomes, while people classified as obese by BMI but with low WC showed no significantly elevated risk. The authors argue clinicians should incorporate central adiposity measurements into routine cardiovascular risk assessment rather than relying solely on BMI.