tl;dr: Google Chrome is removing the final flags and registry workarounds that allowed Manifest V2 extensions like uBlock Origin to keep running, with kExtensionManifestV2Disabled already gone in Chromium 150 and remaining bypass options set to disappear in 151. Edge and Opera are expected to follow, leaving Brave, Vivaldi, and Firefox as the main browsers still supporting the original uBlock Origin; Chrome users are otherwise pushed toward the less capable uBO Lite.